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Cytisine

Jun 02, 2016

     Cytisine is a plant-derived alkaloid that naturally occurs in the Golden Rain (Laburnum anagyroides) and other members of the Leguminosae family.

Cytisine possesses a structure and mechanism of action that are similar to those of nicotine, but it has much lower toxicity. Cytisine is thought to aid smoking cessation by reducing the severity of withdrawal symptoms  and by reducing the reward and satisfaction associated with smoking (via its antagonistic properties).

     The participants were administered either a placebo or Cytisine for 25 days. Both groups received a minimal amount of counseling.The researchers wanted to find out how many participants managed to quit smoking for 12 months after the treatment period was over.

     They found that: 8.4% of those in the cytisine group were abstinent from smoking for 12 months 2.4% of those in the placebo group stayed off tobacco products for 12 monthsIn the cytisine group - the 7-day point prevalence for abstinence from smoking at the 12-month follow up was 13.2%In the placebo group - the 7-day point prevalence for abstinence from smoking at the 12-month follow up was 7.3%The researchers concluded that in this single center trial, cytisine was clearly more effective than placebo in helping people give up smoking.