Jul 11, 2019
Glabridin is also known as glycyrrhiza flavonoids. It is a kind of flavonoids extracted from Glycyrrhiza glabra. Because of its particularity and difficulty of extraction, the price of Glycyrrhiza glabra is relatively high, so Glabridin also has the title of whitening gold.
1. Inhibition of tyrosinase
Human tyrosinase is an essential enzyme that regularly produces melanin, turning skin or eyes from brown to black. We know that skin exposure to ultraviolet light can cause some reactions (such as inflammation). Because the phospholipid membrane of skin tissue is destroyed by reactive oxygen species (ROS) induced by ultraviolet light, this histological change is characterized by erythema and pigmentation. Reactive oxygen species (ROS) are substances that cause skin pigmentation, so inhibiting its production can inhibit the production of melanin.
2. Anti-inflammatory effect
The anti-inflammatory activity of Glabridin was verified by experiments. The pigmentation was induced by ultraviolet irradiation in guinea pigs. Then it was smeared with 0.5% Glabridin solution. It was found that Glabridin alleviated skin inflammation caused by ultraviolet stimulation. A value is used to represent erythema on the skin. The degree of inflammation relief can be calculated by recording the a value of Glabridin before, after and after irradiation. The inhibitory effect of Glabridin on cyclooxygenase activity was studied. Cyclooxygenase is an enzyme that converts arachidonic acid into prostaglandins, which are inflammatory factors. Compared with the control group (using the current cyclooxygenase inhibitor, indomethacin), Glabridin could inhibit the activity of cyclooxygenase. It is believed that Glabridin can reduce inflammation by inhibiting the production of arachidonic acid by inhibiting cyclooxygenase.
3. Antioxidant effect
Glabridin has antioxidant activity, whitening (inhibiting melanin formation) and anti-inflammatory effects. It has been reported that Glycyrrhiza uralensis can be used to reduce the corticosteroids in infectious dermatoses and enhance the steroid effect.
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