Aug 12, 2019
Black cohosh is of the Ranunculaceae genus that grows in eastern North America. It's chemical composition and biologically active ingredient are similar to those of cohosh. Cohosh is a famous Chinese medicine commonly used in China, and its medicinal value has been recorded in the "Shen Nong's Herbal Classic”. Cohosh, slightly sweet, slightly cold, with the effect of publishing rash, clearing away heat and detoxifying, lifting yang.
In recent decades, domestic and foreign scholars have conducted in-depth systematic research on the chemical constituents of cohosh and found hundreds of active ingredient compounds, including triterpenoids and their glycosides, phenolic acids and chromones. Phenolic acids and their derivatives are the main active constituents of the Cimicifuga genus.
In recent years, domestic and foreign scholars have demonstrated through active screening studies that the active ingredients in cohosh have a good inhibitory effect on a variety of human tumor cells. In addition to the triterpenoids, the cohosh’s active composition of ferulic acid also has an anti-tumor effect, which targets the fibroblast growth factor receptor 1 to mediate the PI3K-Akt signaling pathway, inhibiting tumor cell growth and the angiogenesis.
Although the mechanism of inhibition of tumor cells by cohosh needs further studies, its anti-tumor effect is very clear, indicating the feasibility of the active constituents of Cimicifuga in the treatment of tumors. The prospect of using cohosh as a new anti-tumor drug is very optimistic.
It is generally believed that phenolic acids in Cimicifuga are active components of their anti-inflammatory effects, such as ferulic acid, is ferulic acid, and caffeic acid, all of which have been shown to have anti-inflammatory effects. Recent studies have shown that other active components in cohosh also have a certain anti-inflammatory effect.
Studies have found that the active ingredient of cohosh has an antiviral effect. Studies have shown that cohosh can effectively inhibit the formation of plaque caused by a respiratory syncytial virus. And it can inhibit the adsorption of virus and enhance the effect of heparin on virus adsorption.
Although the anti-tumor and anti-viral mechanism of the active ingredient of cohosh is not completely proved, studies have shown that it is closely related to its anti-nucleoside transport.
Studies have shown that the active constituents of cohosh can inhibit the formation of osteoclasts and inhibit osteoclasts from exerting bone resorption, which can effectively protect bone mineral density in ovariectomized mice.
Studies have shown that the total saponin preparation has an antidepressant effect on rodents, and its mechanism may be related to the activation of serotonin and norepinephrine and the normalization of the hypothalamic-pituitary-adrenal axis. At present, there is not much research on the antidepressant effect of cohosh. Compared with the research and development depth of black cohosh, this research direction needs further study.
Cohosh contains polysaccharides and has antioxidant effects. Besides, is ferulic acid, one of the main components of cohosh, can prevent protein saccharification and DNA damage caused by pyruvic aldehyde, and its mechanism of action is to scavenge free radicals.