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Study on the Biological Activity of Psyllium

Dec 10, 2019

        Diuretic effect

        The rat water load model was adopted, and the ethanol extracts of psyllium in different concentrations were used to give medicines. The results showed that the ethanol extracts of Psyllium spp. At doses of 40 and 10 g • kg-1 could increase urine output and the contents of Na +, K +, and Cl- ions in rats, and were effective sites for its diuretic effect. The scientists used a rat water load model and administered different concentrations of psyllium plant extracts. The results showed that psyllium plant extracts could significantly down-regulate the mRNA expression of AQP2, and down-regulate the mRNA expression of AQP1 to a certain extent, but for AQP3 The regulation of mRNA expression was not significant.

         Immunomodulatory effect

        With the deepening of research on the structure and biological activity of polysaccharides, it has been shown that plant polysaccharides have a variety of pharmacological activities such as anti-tumor, anti-virus, anti-oxidation and immune regulation [18-19]. The specific marker of dendritic cells (DCs) is CD11c, which is often used to identify and identify DCs. Tang Yongfu et al. [20] explored the immune regulation mechanism of psyllium chinensis by studying the effect of polysaccharides from psyllium chinensis on DCs phenotype and phagocytosis.

psllium extract

       Studies have shown that the percentage of CD11c-positive cells in each group was 78% after stimulation by the polysaccharide of Psyllium spp., Indicating that the purity of DCs cells in each group was more consistent. When the four kinds of psyllium polysaccharides had a mass concentration of 50 μg • mL-1, the ratios of CD11c + and MHC Ⅱ + double-positive cells were up-regulated. The 80% ethanol extract of Psyllium plantaini was subjected to protein precipitation to obtain a sample (ES-PL) and its effect on the immune system was studied. The results show that ES-PL significantly promotes the maturation of DCs effect. Polysaccharides, ergot saponins, and isosergosides are chemical components isolated from Psyllium, The effects of these components on DCs were discussed, and the results showed that they all had good immune-enhancing activity, which was induced by the maturation of DCs.

        Antioxidant and hypolipidemic effect

       High-fat diet was used to feed healthy adult SD rats to induce hyperlipidemia, and different doses of psyllium were added. The results showed that psyllium reduced rat serum cholesterol (TC), triacylglycerol (TG) and The effect of malondialdehyde (MDA) content is very significant. It has a significant effect on increasing the ratio of high-density lipoprotein cholesterol (HDL-C) to HDL-C / TC, and can also enhance superoxide dismutase (SOD) and peroxidation. Catalase (CAT) activity increases nitric oxide (NO) content.