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Pharmacological Function of Cistanche Extract

Apr 17, 2019

Pharmacological Function of Cistanche Extract

1. Enhance Central Nervous System

For reserpine mice, the content of NE, striatum DA and brain stem 5-HT in hypothalamus can be increased, and the content of 5-HIAA can be reduced. The cistanche extract was continuously administered to rats for 40 days, which increased the content of norepinephrine and 5-hydroxyindole acetic acid in the hypothalamus and increased the ratio of norepinephrine to dihydroxyphenylacetic acid. The dihydroxyphenylacetic acid has a certain increase effect, but has no significant effect on the monoamine neurotransmitters in the marginal brain region.

2. Adjust Endocrine and Metabolic Effects

Cistanche extract can regulate the decrease and increase of liver and spleen nucleic acid content in yang deficiency and yin deficiency animals. It can activate corticosteroids to activate the adrenal gland; enhance the corpus luteum function of hypothalamic-pituitary-ovary and improve the pituitary to LRH Reactive and ovarian luteinizing function, improve the responsiveness of pituitary to LRH and ovarian response to LH without affecting the endocrine balance of the natural reproductive cycle; Cistanche extract Some organic acids have a role in promoting salivation in mice Function; can increase the synthesis of DNA in the liver of yang deficiency animals; promote the synthesis of RNA; increase the nucleic acid metabolism of protein; use the dilute alcohol extract to feed the rats in water, which promotes the growth and development; can prolong the life of some animals.

3. Impact on Immune System

The mice were given an aqueous solution of Cistanche at 50-100 mg per kilogram to increase the weight of the spleen and thymus; increase the phagocytic rate of macrophages; increase the value of hemolysin and hemolytic plaque; increase the cAMP content in peritoneal macrophages, and cGMP Reduced content; increased lymphocyte transformation rate, increased 3H-TdR content infiltrated into lymphocytes; can enhance delayed hypersensitivity. The low concentration of Cistanche deserticola (5mg/mL) can increase the Ea flowering rate of normal human peripheral blood lymphocytes, but has no effect on the Et flowering rate, while the high concentration (50mg/mL) can reduce the Et flowering rate. Cistanche deserticola can reduce the percentage of ANAE+ lymphocytes at high concentrations and low concentrations. The mice were given 60% Cistanche decoction 0.5 mL for 8 consecutive days, which enhanced the footpad reaction after SRBC challenge.

4. Androgen-like Function

The crude extract of Cistanche deserticola has an androgenic effect, which can increase the weight of the accessory organs such as the seminal vesicle prostate. The betaine and ergot isolated from Cistanche deserticola have the same androgen-like action, in which the action of betaine is stronger than that of crude extract, and it is presumed that betaine and ergot are the main active components of androgen-like action of Cistanche. The phenylethyl hydrazines isolated from this product, including ergot, also have an improved sexual function.

5. Antioxidant Effect

Ethanol extract of Cistanche tubulosa can significantly inhibit the formation of lipid peroxide in rat brain, liver, heart, kidney and testis tissue in vitro, and it is dose-effect relationship. Continuous gavage significantly inhibited the production of lipid peroxides in rat cerebral cortex, but had no significant effect on other tissues; it significantly enhanced plasma superoxide dismutase activity.

6. Laxative Effect

Cistanche extract can significantly shorten the laxative time of mice and promote defecation; it can significantly improve the intestinal propulsion of mice and enhance the function of intestinal peristalsis; it can effectively counteract the inhibitory effect of atropine on mice; The moisture absorption has an inhibitory effect.

7. Other Effects

The ethanol extract of Cistanche can resist the sexual behavior and learning ability of male mice caused by chronic suspension stress. The effect of hydrocortisone "yang deficiency" mice on the DNA synthesis rate of liver and spleen. There is a significant inhibition of liver toxicity caused by CCl4. Oral administration of water decoction in mice can significantly increase their body weight, prolong the swimming time, improve the ability to resist hypoxia, and decrease the serum creatine kinase level after exercise. The ultrastructure shows that the muscle glycogen content of skeletal muscle is rich. The mitochondria are generally hypertrophied and the myofibrils are intact and intact. The serum urea nitrogen content of the mice in the exercise group was lower than that of the control group; the endoplasmic reticulum of the liver was hyperplasia and hypertrophy, and no granule protein appeared in the exercise group after the exercise, and the endoplasmic reticulum pool was expanded. It can antagonize protein decomposition and adjust cell ultrastructure to promote protein synthesis. The reduced body weight growth rate, freezing time, red blood cell SOD activity and hemoglobin content of the "yang deficiency" mice returned to normal to some extent. Animals using corticosteroids for a long period of time with the addition of Cistanche alcohol extract can prevent adrenocortical atrophy caused by hormone alone, and also have a certain protective effect on renal function.


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