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How can hops flavone be produced on a large scale

Nov 26, 2019

       Hops (Humulus pulpulus), scientific name is hops, tang grass flowers, etc, is a creeping perennial climbing herb of the genus Morinaceae. Hops, as a long-established medicinal and food homologous plant, is complex in composition and contains more than ten types of chemicals, including resins, volatile oils, flavones, tannins, choline, crude fiber, and amino acids. China's hop resources are abundant, and its total output is in the leading position in the world. Hops have anti-tuberculosis, soothe the diuretic and stomach-eliminating effects. At present, hops are used for a single purpose, mainly for the beer brewing industry, but other uses have not been fully utilized. Isolation and extraction of active ingredients of hops is of great significance for expanding the medicinal value of hops, especially the application of hops in medicine, food and other fields. The content of flavonoids in hops ranges from 6% to 8%. Among them, there are three main types: chalcones, flavones and flavans.

        Even domestic and foreign research reports on the purification process of hop flavonoids are few. So how can hops flavone be produced on a large scale in practice?

hop flavonoids

      The hop flavone was separated and purified by ethanol extraction and macroporous resin adsorption, and the process parameters were optimized according to the flavonoid content and yield to establish a hop flavone preparation process suitable for large-scale production. Methods: On the basis of ethanol extraction of hop flavones, macroporous resin static adsorption and elution methods were used to isolate and purify hop flavones. The optimal process parameters were determined based on the extraction results, adsorption rate and elution rate.

       Results: The optimum process conditions were volume fraction extraction with 40% ethanol, using FL-3 macroporous resin, static adsorption with pH value of 4, 20% ethanol, and elution with pH value of 60, 60% ethanol solution. . The content of flavonoids in the samples prepared according to this process was 70.6%, and the yield was 70.2%. Conclusion: Ethanol extraction combined with the static adsorption method of FL-3 macroporous resin can separate and purify hop flavone; this process is easy to operate and has a large sample processing capacity, which is suitable for large-scale production.